42 days in South America Itinerary

42 days in South America Itinerary

Created using Inspirock South America holiday planner

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1
San Andres Island, Colombia
— 2 nights
2
Bogota, Colombia
— 2 nights
3
Tayrona National Park, Colombia
— 2 nights
4
Cartagena, Colombia
— 2 nights
5
Margarita Island, Venezuela
— 6 nights
6
Coro, Venezuela
— 3 nights
7
Caracas, Venezuela
— 2 nights
8
Arequipa, Peru
— 2 nights
9
Maras, Peru
— 2 nights
10
Machu Picchu, Peru
— 2 nights
11
Cusco, Peru
— 2 nights
12
Lima, Peru
— 2 nights
13
Cuenca, Ecuador
— 2 nights
14
Quito, Ecuador
— 2 nights
15
Puerto Villamil, Ecuador
— 2 nights
16
Puerto Ayora, Ecuador
— 3 nights
17
Puerto Baquerizo Moreno, Ecuador
— 1 night

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2
nights
San Andres Island, Colombia

San Andres Island ©
The coral San Andres Island boasts a rich colonial history, exotic beaches, and a laidback, tropical lifestyle.
Start off your visit on the 2nd (Sat): add some adventure to your tour with EcoFiwi Turismo Ecologico, then Head underground at Morgan's Cave, and then pause for some serene contemplation at Primera Iglesia Bautista. Get ready for a full day of sightseeing on the 3rd (Sun): look for all kinds of wild species at La Piscinita and then kick back and relax at Playa de San Luis.

To see more things to do, other places to visit, maps, and tourist information, go to the San Andres Island trip planner.

San Francisco, USA to San Andres Island is an approximately 16-hour flight. The time zone difference moving from Pacific Standard Time (PST) to Colombia Standard Time (COT) is 3 hours. Plan for much warmer temperatures traveling from San Francisco in January, with highs in San Andres Island at 84°F and lows at 76°F. Cap off your sightseeing on the 3rd (Sun) early enough to travel to Bogota.

Things to do in San Andres Island

Parks · Outdoors · Wildlife · Nature
Highlights from your plan
Morgan's Cave ©
Morgan's Cave
EcoFiwi Turismo Ecologico ©
EcoFiwi Turismo Ecologico
La Piscinita ©
La Piscinita

2
nights
Bogota, Colombia

Bogota ©

Athens of South America

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Start off your visit on the 4th (Mon): don't miss a visit to Bolivar Square, then explore the world behind art at Museo Botero del Banco de la Republica, and then tour the pleasant surroundings at Monserrate. Keep things going the next day: take in the architecture and atmosphere at Catedral de Sal de Zipaquira and then see the interesting displays at Gold Museum (Museo del Oro).

To find ratings, traveler tips, photos, and more tourist information, read our Bogota trip builder tool.

Fly from San Andres Island to Bogota in 4.5 hours. While traveling from San Andres Island, expect a bit cooler days and colder nights in Bogota, ranging from highs of 68°F to lows of 44°F. Cap off your sightseeing on the 5th (Tue) early enough to travel to Tayrona National Park.

Things to do in Bogota

Museums · Historic Sites · Nature · Parks

Side Trip

Highlights from your plan
Gold Museum (Museo del Oro) ©
Gold Museum (Museo del Oro)
Catedral de Sal de Zipaquira ©
Catedral de Sal de Zipaquira
Museo Botero del Banco de la Republica ©
Museo Botero del Banco de la Republica

2
nights
Tayrona National Park, Colombia

Tayrona National Park ©
On the 6th (Wed), explore the striking landscape of Parque Nacional Natural Tayrona. Get ready for a full day of sightseeing on the 7th (Thu): look for all kinds of wild species at El Dorado Bird Reserve and then head outdoors with Pozo Azul.

To plan Tayrona National Park vacation without wasting time, ask Inspirock to design an itinerary.

You can fly from Bogota to Tayrona National Park in 4.5 hours. Alternatively, you can drive; or do a combination of bus and taxi. In January, Tayrona National Park is warmer than Bogota - with highs of 92°F and lows of 74°F. Cap off your sightseeing on the 7th (Thu) early enough to go by car to Cartagena.

Things to do in Tayrona National Park

Parks · Nature · Wildlife · Outdoors

Side Trip

Highlights from your plan
Parque Nacional Natural Tayrona ©
Parque Nacional Natural Tayrona
El Dorado Bird Reserve ©
El Dorado Bird Reserve
Pozo Azul ©
Pozo Azul

2
nights
Cartagena, Colombia

Cartagena ©

City of Heroes

The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Kick off your visit on the 8th (Fri): contemplate the long history of Walled City of Cartagena, take in the architecture and atmosphere at Sanctuary of Saint Peter Claver, then step into the grandiose world of Castillo de San Felipe de Barajas, and finally pause for some photo ops at Monumento a Los Zapatos Viejos. On the next day, take in the architecture and atmosphere at Iglesia de la Tercera Orden, contemplate in the serene atmosphere at Convent of Santa Cruz de la Popa, then deepen your understanding at Plaza Santo Domingo, then steep yourself in history at Torre del Reloj, and finally don't miss a visit to Plaza de los Coches.

To see where to stay, ratings, maps, and more tourist information, go to the Cartagena online day trip planner.

Drive from Tayrona National Park to Cartagena in 4 hours. Alternatively, you can do a combination of taxi and bus. In January, daily temperatures in Cartagena can reach 88°F, while at night they dip to 75°F. Finish up your sightseeing early on the 9th (Sat) so you can travel to Margarita Island.

Things to do in Cartagena

Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo de San Felipe de Barajas ©
Castillo de San Felipe de Barajas
Plaza Santo Domingo ©
Plaza Santo Domingo

6
nights
Margarita Island, Venezuela

Margarita Island ©

Pearl of the Caribbean

A popular holiday spot for Venezuelans, sunny Margarita Island boasts an exotic Caribbean location, but at the same time is easily accessible from the mainland.
Get outdoors at Laguna de la Restinga and Playa Parguito. Deepen your sense of the past at sights like Fortín La Galera and Basilica Nuestra Senora Del Valle. And it doesn't end there: kick back and relax at Playa El Agua, get outside with Playa Caribe, step off the mainland to explore El Farallon Isla Blanca, and explore the historical opulence of Castillo de Santa Rosa.

To see photos, where to stay, and other tourist information, use the Margarita Island trip website.

Traveling by flight from Cartagena to Margarita Island takes 9 hours. Alternatively, you can do a combination of car and ferry. The time zone changes from Colombia Standard Time to Venezuela Time, which is usually a 1 hour difference. January in Margarita Island sees daily highs of 88°F and lows of 77°F at night. Finish your sightseeing early on the 16th (Sat) so you can travel to Coro.

Things to do in Margarita Island

Parks · Outdoors · Beaches · Historic Sites
Highlights from your plan
Laguna de la Restinga ©
Laguna de la Restinga
Fortín La Galera
Fortín La Galera
Playa El Agua ©
Playa El Agua

3
nights
Coro, Venezuela

Coro ©
The oldest city in western Venezuela, Coro was founded in 1527 and possesses a rich, varied cultural heritage.
Do some cultural sightseeing at Plaza San Clemente and Medanos de Coro. Deepen your sense of the past at sights like Iglesia San Francisco and Catedral Basilica de Santa Ana de Coro. And it doesn't end there: head outdoors with Cataratas de Hueque, see the interesting displays at Casa De Las Ventanas De Hierro, and don't miss a visit to Casa del Sol.

For reviews, where to stay, more things to do, and other tourist information, you can read our Coro online travel route planner.

You can do a combination of flight and taxi from Margarita Island to Coro in 7.5 hours. Other options are to do a combination of car and ferry; or do a combination of taxi, ferry, and bus. In January, daytime highs in Coro are 91°F, while nighttime lows are 77°F. Finish up your sightseeing early on the 19th (Tue) so you can travel to Caracas.

Things to do in Coro

Historic Sites · Museums · Outdoors
Highlights from your plan
Iglesia San Francisco ©
Iglesia San Francisco
Medanos de Coro ©
Medanos de Coro
Plaza San Clemente ©
Plaza San Clemente

2
nights
Caracas, Venezuela

Caracas ©

Heaven's Branch on Earth

Tropical weather, great food, and memorable jungle surroundings seem like all the ingredients Caracas needs to become a must-see destination.
Start off your visit on the 20th (Wed): take in the architecture and atmosphere at Iglesia Nuestra Senora de Las Mercedes, then get outside with Parque Nacional el Avila, then take in the exciting artwork at Hacienda La Trinidad Parque Cultural, and finally take in the architecture and atmosphere at Iglesia Sagrado Corazon de Jesus.

For other places to visit, traveler tips, maps, and other tourist information, read our Caracas itinerary planner.

You can fly from Coro to Caracas in 4.5 hours. Alternatively, you can drive; or take a bus. Wrap up your sightseeing by early afternoon on the 21st (Thu) to allow enough time to travel to Arequipa.

Things to do in Caracas

Highlights from your plan
Parque Nacional el Avila ©
Parque Nacional el Avila
Casa Natal & Museo Bolivar ©
Casa Natal & Museo Bolivar
Hacienda La Trinidad Parque Cultural ©
Hacienda La Trinidad Parque Cultural

2
nights
Arequipa, Peru

Arequipa ©

White City

In an area dominated three imposing volcanoes, Arequipa vacations allow visitors to admire well-preserved colonial architecture in a dramatic setting.
On the 22nd (Fri), look for gifts at La Iberica, contemplate the long history of Historic Centre of Arequipa, see the interesting displays at Santa Catalina Monastery, then get engrossed in the history at Museo Santuarios Andinos, and finally appreciate the extensive heritage of Iglesia de la Compania de Jesus. Get ready for a full day of sightseeing on the next day: admire the landmark architecture of Plaza de Armas and then contemplate the geological forces at Volcan Misti.

To find more things to do, maps, reviews, and more tourist information, refer to the Arequipa road trip planning site.

Getting from Caracas to Arequipa by flight takes about 11 hours. Other options: drive; or do a combination of bus and car. You'll gain 1 hour traveling from Caracas to Arequipa due to the time zone difference. January in Arequipa sees daily highs of 68°F and lows of 52°F at night. Cap off your sightseeing on the 23rd (Sat) early enough to travel to Maras.

Things to do in Arequipa

Historic Sites · Museums · Nature · Parks
Highlights from your plan
Historic Centre of Arequipa ©
Historic Centre of Arequipa
Santa Catalina Monastery ©
Santa Catalina Monastery
Museo Santuarios Andinos ©
Museo Santuarios Andinos

2
nights
Maras, Peru

Maras ©
Maras is a town in the Sacred Valley of the Incas, 40 kilometers north of Cuzco, in the Cuzco Region of Peru. On the 24th (Sun), delve into the distant past at Moray and then contemplate the long history of Salinas de Maras. Here are some ideas for day two: glide peacefully along the water with Huaypo Green and then make a trip to Iglesia San Martin de Tours.

To find where to stay, traveler tips, photos, and more tourist information, refer to the Maras driving holiday site.

Traveling by flight from Arequipa to Maras takes 4 hours. Alternatively, you can drive; or do a combination of bus and taxi. Traveling from Arequipa in January, expect slightly colder with lows of 46°F in Maras. Wrap up your sightseeing by early afternoon on the 25th (Mon) to allow enough time to travel to Machu Picchu.

Things to do in Maras

Historic Sites · Tours · Nature · Adventure

Side Trips

Highlights from your plan
Salinas de Maras ©
Salinas de Maras
Moray ©
Moray

2
nights
Machu Picchu, Peru

Machu Picchu ©
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Kick off your visit on the 26th (Tue): take in nature's colorful creations at Mandor and then delve into the distant past at Santuario Historico de Machu Picchu. On the next day, don't miss a visit to Plaza Manco Capac, take in the natural beauty of Hot Springs (Aguas Calientes), and then take some stellar pictures from Intipuncu.

To find more things to do, ratings, maps, and other tourist information, refer to the Machu Picchu trip itinerary site.

Traveling by combination of taxi and train from Maras to Machu Picchu takes 3 hours. Alternatively, you can drive. Finish your sightseeing early on the 27th (Wed) so you can travel to Cusco.

Things to do in Machu Picchu

Historic Sites · Parks · Nature · Wildlife
Highlights from your plan
Santuario Historico de Machu Picchu ©
Santuario Historico de Machu Picchu
Intipuncu ©
Intipuncu
Mandor ©
Mandor

2
nights
Cusco, Peru

Cusco ©

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Kick off your visit on the 28th (Thu): delve into the distant past at Qorikancha, steep yourself in history at Sacsayhuaman, and then steep yourself in history at Plaza de Armas. Here are some ideas for day two: surround yourself with nature on a nature and wildlife tour.

Find out how to plan Cusco trip without stress by asking Inspirock to help create an itinerary.

Traveling by combination of train and bus from Machu Picchu to Cusco takes 4 hours. Alternatively, you can take a train; or drive. In January in Cusco, expect temperatures between 67°F during the day and 46°F at night. Finish your sightseeing early on the 29th (Fri) so you can travel to Lima.

Things to do in Cusco

Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Qorikancha ©
Qorikancha
Plaza de Armas ©
Plaza de Armas

2
nights
Lima, Peru

Lima ©

City of the Kings

Founded in 1535 by Spanish explorer Francisco Pizarro, Lima represents an interesting blend of modern attractions and preserved colonial architecture, much of it clustered in the World Heritage-listed city center.
Start off your visit on the 30th (Sat): wander the streets of Miraflores, contemplate the long history of Huaca Pucllana, then appreciate the extensive heritage of Centro Historico de Lima, and finally get engrossed in the history at Museo Convento San Francisco y Catacumbas.

For more things to do, other places to visit, and tourist information, go to the Lima trip planning tool.

Getting from Cusco to Lima by flight takes about 3.5 hours. Other options: drive; or take a bus. Traveling from Cusco in January, expect nights in Lima to be warmer, around 69°F, while days are somewhat warmer, around 80°F. Wrap up your sightseeing by early afternoon on the 31st (Sun) to allow enough time to travel to Cuenca.

Things to do in Lima

Highlights from your plan
Huaca Pucllana ©
Huaca Pucllana
Museo Convento San Francisco y Catacumbas ©
Miraflores ©
Miraflores

2
nights
Cuenca, Ecuador

Cuenca ©

Athens of Ecuador

Packed with impressive colonial architecture and a historic town center, Cuenca stands as perhaps the most charming city in the nation.
Start off your visit on the 1st (Mon): contemplate the waterfront views at Rio Tomebamba, explore the wealth of natural beauty at El Cajas National Park, contemplate the long history of Plaza de las flores, then admire the striking features of Inmaculada Concepción Cathedral, and finally admire the majestic nature at Plaza Abdon Calderon. Get ready for a full day of sightseeing on the 2nd (Tue): take an in-depth tour of Pumapungo Museum and Arqueological Park - MCYP, take in the architecture and atmosphere at Mirador de Turi, then take in the exciting artwork at Homero Ortega, and finally contemplate the long history of Museo Catedral Vieja.

To see more things to do, photos, where to stay, and more tourist information, refer to the Cuenca trip builder tool.

Fly from Lima to Cuenca in 7 hours. Alternatively, you can drive; or take a bus. Prepare for a bit cooler weather when traveling from Lima in January: high temperatures in Cuenca hover around 73°F and lows are around 53°F. Wrap up your sightseeing on the 2nd (Tue) early enough to travel to Quito.

Things to do in Cuenca

Nature · Parks · Historic Sites · Museums
Highlights from your plan
El Cajas National Park ©
El Cajas National Park
Museo Catedral Vieja ©
Museo Catedral Vieja
Mirador de Turi ©
Mirador de Turi

2
nights
Quito, Ecuador

Quito ©

Light of America

High in the Andean foothills, Quito remains one of the world's most photogenic capital cities, featuring two dramatic mountain ranges as its backdrop.
Start off your visit on the 3rd (Wed): take in the spiritual surroundings of Basilica del Voto Nacional, then take in the architecture and atmosphere at Iglesia y Convento de San Francisco, then admire the striking features of Fundacion Iglesia de la Compania, and finally get to know the fascinating history of Quito Old Town. Get ready for a full day of sightseeing on the next day: identify plant and animal life at Adventure Journeys.

To find traveler tips, reviews, more things to do, and more tourist information, read Quito trip builder.

You can fly from Cuenca to Quito in 3 hours. Other options are to drive; or take a bus. In February in Quito, expect temperatures between 70°F during the day and 57°F at night. Wrap up your sightseeing by early afternoon on the 4th (Thu) to allow time for travel to Puerto Villamil.

Things to do in Quito

Historic Sites · Wildlife · Tours · Adventure
Highlights from your plan
Fundacion Iglesia de la Compania ©
Fundacion Iglesia de la Compania
Adventure Journeys ©
Adventure Journeys
Iglesia y Convento de San Francisco ©
Iglesia y Convento de San Francisco

2
nights
Puerto Villamil, Ecuador

Puerto Villamil ©
Located in the southeast of Isla Isabela, Puerto Villamil is home to the majority of the island's 2,200 inhabitants.
Kick off your visit on the 5th (Fri): explore the activities along Laguna de los Diablos, contemplate the waterfront views at Laguna Salinas, then get outside with Outdoor Activities, then step off the mainland to explore Las Tintoreras, and finally take in the architecture and atmosphere at Iglesia Cristo Salvador. Keep things going the next day: stroll through Concha de Perla, then take in the waterfront at Malecon Cuna del Sol, then stroll through El Tunel del Estero, and finally enjoy the sand and surf at Playa Puerto Villamil.

To see reviews, photos, other places to visit, and other tourist information, read Puerto Villamil trip planner.

Getting from Quito to Puerto Villamil by flight takes about 6 hours. Traveling from Quito to Puerto Villamil, you'll gain 1 hour due to the time zone difference. Finish your sightseeing early on the 6th (Sat) so you can ride a ferry to Puerto Ayora.

Things to do in Puerto Villamil

Parks · Outdoors · Nature · Wildlife
Highlights from your plan
Concha de Perla ©
Concha de Perla
Stand-Up Paddleboarding
Iglesia Cristo Salvador ©
Iglesia Cristo Salvador

3
nights
Puerto Ayora, Ecuador

Puerto Ayora ©
The largest settlement in the Galapagos, Puerto Ayora offers visitors to the islands an array of facilities and things to do.
Kick off your visit on the 7th (Sun): shop like a local with Galeria Aymara, take in the dramatic natural features at Las Grietas, and then stroll through Charles Darwin Research Station. Get ready for a full day of sightseeing on the next day: take an in-depth tour of Maprae, explore the world behind art at Galeria Exotico Ecuador, take in the exciting artwork at Maki-Art Gallery, shop like a local with The Angelique Art Gallery, then pause for some photo ops at Monumento de aves de Galapagos, and finally kick back and relax at Galapagos Beach at Tortuga Bay.

To find ratings, reviews, traveler tips, and other tourist information, go to the Puerto Ayora day trip planner.

Traveling by ferry from Puerto Villamil to Puerto Ayora takes 3.5 hours. You'll lose 1 hour traveling from Puerto Villamil to Puerto Ayora due to the time zone difference. In February, daytime highs in Puerto Ayora are 87°F, while nighttime lows are 75°F. Wrap up your sightseeing on the 9th (Tue) to allow time to ride a ferry to Puerto Baquerizo Moreno.

Things to do in Puerto Ayora

Parks · Museums · Shopping · Wildlife

Side Trip

Highlights from your plan
Charles Darwin Research Station ©
Charles Darwin Research Station
Galapagos Beach at Tortuga Bay ©
Galapagos Beach at Tortuga Bay
Galeria Aymara ©
Galeria Aymara

1
night
Puerto Baquerizo Moreno, Ecuador

Puerto Baquerizo Moreno ©
The capital of the Galapagos Islands, Puerto Baquerizo Moreno is located on easternmost island of the archipelago, San Cristobal.
Start off your visit on the 9th (Tue): explore the wealth of natural beauty at Cerro Tijeretas. On the next day, pause for some serene contemplation at Catedral Inmaculada Concepcion, then enjoy the sand and surf at Puerto Chino Beach, and then learn more about the world around you at Interpretation Center.

For traveler tips, reviews, and tourist information, read our Puerto Baquerizo Moreno travel route site.

Traveling by ferry from Puerto Ayora to Puerto Baquerizo Moreno takes 3.5 hours. In February, daily temperatures in Puerto Baquerizo Moreno can reach 87°F, while at night they dip to 75°F. Cap off your sightseeing on the 10th (Wed) early enough to travel back home.

Things to do in Puerto Baquerizo Moreno

Parks · Wildlife · Nature · Beaches

Side Trip

Highlights from your plan
Cerro Tijeretas ©
Cerro Tijeretas
Interpretation Center ©
Interpretation Center
Catedral Inmaculada Concepcion ©
Catedral Inmaculada Concepcion